NEWS

Alcohol and histamine can be a problematic combination for sensitive individuals. It is not only about the histamine contained in a particular drink. Alcohol may also impair the body's ability to break down histamine, while DAO (diamine oxidase) acts as the main enzymatic barrier against histamine consumed through food.¹⁻³ This is why someone may tolerate a glass of wine or a particular food on its own, but experience symptoms when the two are combined. Over the course of an

Histamine does not act only in the digestive system. Through H1–H4 receptors, it also influences the nervous, vascular, and immune systems. In the central nervous system, histamine functions as a neurotransmitter and is involved, among other things, in regulating wakefulness and neural signaling.¹ Headaches, migraine-like symptoms, and dizziness have also been reported in people with suspected histamine intolerance. In a clinical study involving 133 patients, headaches and di

The key point is that DAO protects the body from exogenous histamine – both histamine from food and histamine produced by the gut microbiota.¹ This is precisely the principle described in the scientific review by Comas-Basté et al.: DAO plays a major role in protecting the body from exogenous histamine originating from food as well as histamine produced by the gut microbiota.¹ When discussing histamine, we sometimes encounter the claim that only 10% of histamine comes from fo